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1

Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic Probes for glycosyltransferases

Michael D Burkart, Stéphane P Vincent, Arno Düffels, Brion W Murray, Steven V Ley, Chi-Huey Wong

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 295 KB

english, 2000

2

Cyclic Amidine Sugars as Transition-State Analogue Inhibitors of Glycosidases: Potent Competitive Inhibitors of Mannosidases.

Marie-Pierre Heck, Stephane P. Vincent, Brion W. Murray, Francois Bellamy, Chi-Huey Wong, Charles Mioskowski

Journal:

Year:

2004

Language:

english

File:

PDF, 143 KB

english, 2004

3

Structure-based design of novel human Pin1 inhibitors (II)

Liming Dong, Joseph Marakovits, Xinjun Hou, Chuangxing Guo, Samantha Greasley, Eleanor Dagostino, RoseAnn Ferre, M. Catherine Johnson, Eugenia Kraynov, James Thomson, Ved Pathak, Brion W. Murray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 702 KB

english, 2010

4

Protein–inhibitor complexes analyzed by alkaline capillary LC–MS

Stone D.-H. Shi, Michael J. Greig, James E. Solowiej, Brion W. Murray

Journal:

Journal of Chromatography B

Year:

2005

Language:

english

File:

PDF, 1.21 MB

english, 2005

5

A chemoenzymatic synthesis of UDP-(2-deoxy-2-fluoro)galactose and evaluation of its interaction with galactosyltransferase

Takashi Hayashi, Brion W Murray, Ruo Wang, Chi-Huey Wong

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 385 KB

english, 1997

6

Protein kinase biochemistry and drug discovery

Phillip A. Schwartz, Brion W. Murray

Journal:

Bioorganic Chemistry

Year:

2011

Language:

english

File:

PDF, 722 KB

english, 2011

7

Identification and characterization of a novel and functional murine Pin1 isoform

Jeff X. Zhu, Eleanor Dagostino, Paul A. Rejto, Barbara Mroczkowski, Brion Murray

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 961 KB

english, 2007

8

Meta-Analysis of 13 Genome Scans Reveals Multiple Cleft Lip/Palate Genes with Novel Loci on 9q21 and 2q32-35

Mary L. Marazita, Jeffrey C. Murray, Andrew C. Lidral, Mauricio Arcos-Burgos, Margaret E. Cooper, Toby Goldstein, Brion S. Maher, Sandra Daack-Hirsch, Rebecca Schultz, M. Adela Mansilla, L. Leigh Fiel

Journal:

The American Journal of Human Genetics

Year:

2004

Language:

english

File:

PDF, 1.44 MB

english, 2004

9

Characterizing the Effects of the Juxtamembrane Domain on Vascular Endothelial Growth Factor Receptor-2 Enzymatic Activity, Autophosphorylation, and Inhibition by Axitinib

Solowiej, James, Bergqvist, Simon, McTigue, Michele A., Marrone, Tami, Quenzer, Terri, Cobbs, Morena, Ryan, Kevin, Kania, Robert S., Diehl, Wade, Murray, Brion W.

Journal:

Year:

2009

Language:

english

File:

PDF, 1.06 MB

english, 2009

10

Substrate-Specific Conformational Regulation of the Receptor Tyrosine Kinase VEGFR2 Catalytic Domain

Solowiej, James, Chen, Jeffrey H., Zou, Helen Y., Grant, Stephan K., Murray, Brion W.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 739 KB

english, 2013

11

Mechanistic Effects of Autophosphorylation on Receptor Tyrosine Kinase Catalysis: Enzymatic Characterization of Tie2 and Phospho-Tie2

Murray, Brion W., Padrique, Ellen S., Pinko, Chris, McTigue, Michele A.

Journal:

Year:

2001

Language:

english

File:

PDF, 155 KB

english, 2001

12

Cyclic Amidine Sugars as Transition-State Analogue Inhibitors of Glycosidases: Potent Competitive Inhibitors of Mannosidases

Heck, Marie-Pierre, Vincent, Stéphane P., Murray, Brion W., Bellamy, François, Wong, Chi-Huey, Mioskowski, Charles

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 166 KB

english, 2004

13

Enzymatic Characterization of c-Met Receptor Tyrosine Kinase Oncogenic Mutants and Kinetic Studies with Aminopyridine and Triazolopyrazine Inhibitors

Timofeevski, Sergei L., McTigue, Michele A., Ryan, Kevin, Cui, Jean, Zou, Helen Y., Zhu, Jeff X., Chau, Fannie, Alton, Gordon, Karlicek, Shannon, Christensen, James G., Murray, Brion W.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.10 MB

english, 2009

14

A simple and efficient maleimide-based approach for peptide extension with a cysteine-containing peptide phage library

Santoso, Buyung, Lam, Son, Murray, Brion W., Chen, Gang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 484 KB

english, 2013

15

Why Is CMP-Ketodeoxyoctonate Highly Unstable? †

Lin, Chun-Hung, Murray, Brion W., Ollmann, Ian R., Wong, Chi-Huey

Journal:

Year:

1997

Language:

english

File:

PDF, 127 KB

english, 1997

16

Mechanism and Specificity of Human α-1,3-Fucosyltransferase V †

Murray, Brion W., Takayama, Shuichi, Schultz, Jody, Wong, Chi-Huey

Journal:

Year:

1996

Language:

english

File:

PDF, 743 KB

english, 1996

17

Mechanism of Human α-1,3-Fucosyltransferase V: Glycosidic Cleavage Occurs Prior to Nucleophilic Attack †

Murray, Brion W., Wittmann, Valentin, Burkart, Michael D., Hung, Shang-Cheng, Wong, Chi-Huey

Journal:

Year:

1997

Language:

english

File:

PDF, 283 KB

english, 1997

18

Steady-State and Pre-Steady-State Kinetic Evaluation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL pro Cysteine Protease: Development of an Ion-Pair Model for Catalysis

Solowiej, James, Thomson, James A., Ryan, Kevin, Luo, Chun, He, Mingying, Lou, Jihong, Murray, Brion W.

Journal:

Year:

2008

Language:

english

File:

PDF, 186 KB

english, 2008

19

Synergistic Inhibition of Human α-1,3-Fucosyltransferase V

Qiao, Lei, Murray, Brion W., Shimazaki, Makoto, Schultz, Jody, Wong, Chi-Huey

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 472 KB

english, 1996

20

Molecular properties of pyruvate formate-lyase activating enzyme

Wong, Kenny K., Murray, Brion W., Lewisch, Sandra A., Baxter, Michael K., Ridky, Todd W., Ulissi-DeMario, Lucy, Kozarich, John W.

Journal:

Year:

1993

Language:

english

File:

PDF, 1.90 MB

english, 1993

21

Cyclic Guanidino-Sugars with Low p K a as Transition-State Analog Inhibitors of Glycosidases: Neutral Instead of Charged Species Are the Active Forms

Jeong, Jin-Hyun, Murray, Brion W., Takayama, Shuichi, Wong, Chi-Huey

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 353 KB

english, 1996

22

[Methods in Enzymology] Part F: Regulators and Effectors of Small GTPases Volume 332 || Analysis of pharmacologic inhibitors of Jun N-terminal kinases

Murray, Brion W.

Year:

2001

Language:

english

File:

PDF, 1.34 MB

english, 2001

23

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Pemovska, Tea, Johnson, Eric, Kontro, Mika, Repasky, Gretchen A., Chen, Jeffrey, Wells, Peter, Cronin, Ciarán N., McTigue, Michele, Kallioniemi, Olli, Porkka, Kimmo, Murray, Brion W., Wennerberg, Kris

Journal:

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

24

A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer

Mitri, Zahi, Karakas, Cansu, Wei, Caimiao, Briones, Brian, Simmons, Holly, Ibrahim, Nuhad, Alvarez, Ricardo, Murray, James L., Keyomarsi, Khandan, Moulder, Stacy

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 529 KB

english, 2015

25

An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations

Kuzmič, Petr, Solowiej, James, Murray, Brion W.

Journal:

Analytical Biochemistry

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

26

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

Wani, Revati, Nagata, Asako, Murray, Brion W.

Journal:

Frontiers in Pharmacology

Year:

2014

Language:

english

File:

PDF, 863 KB

english, 2014

27

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Brion W. Murray, Chuangxing Guo, Joseph Piraino, John K. Westwick, Cathy Zhang, Jane Lamerdin, Eleanor Dagostino, Daniel Knighton, Cho-Ming Loi, Michael Zager, Eugenia Kraynov, Ian Popoff, James G. Ch

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.39 MB

english, 2010

28

Discovery of 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988), A Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W., Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Douglas Carl, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P., Feng, Jun Li,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 4.17 MB

english, 2016

29

Genome Scan, Fine-Mapping, and Candidate Gene Analysis of Non-Syndromic Cleft Lip with or without Cleft Palate Reveals Phenotype-Specific Differences in Linkage and Association Results

Marazita, Mary L., Lidral, Andrew C., Murray, Jeffrey C., Field, L.Leigh, Maher, Brion S., Goldstein McHenry, Toby, Cooper, Margaret E., Govil, Manika, Daack-Hirsch, Sandra, Riley, Bridget, Jugessur,

Journal:

Year:

2009

Language:

english

File:

PDF, 518 KB

english, 2009

30

Recent Progress on Third Generation Covalent EGFR Inhibitors

Cheng, Hengmiao, Nair, Sajiv K., Murray, Brion W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 472 KB

english, 2016

31

ChemInform Abstract: Recent Progress on Third Generation Covalent EGFR Inhibitors

Cheng, Hengmiao, Nair, Sajiv K., Murray, Brion W.

Journal:

Year:

2016

File:

PDF, 16 KB

2016

32

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

Mercurio, Frank, Murray, Brion W., Shevchenko, Andrej, Bennett, Brydon L., Young, David B., Li, Jian Wu, Pascual, Gabriel, Motiwala, Aparna, Zhu, Hengyi, Mann, Matthias, Manning, Anthony M.

Journal:

Molecular and Cellular Biology

Year:

1999

Language:

english

File:

PDF, 3.01 MB

english, 1999

33

Genomic profiling and treatment of HER2+, ER+, PgR+ “triple positive” breast cancer: A case report and literature review

Schwab, Richard B., Koehler, Maria, Ali, Siraj M., Murray, Brion W.

Journal:

Cancer Treatment and Research Communications

Year:

2016

Language:

english

File:

PDF, 272 KB

english, 2016

34

The Axl Kinase Domain in Complex with a Macrocyclic Inhibitor Offers First Structural Insights into an Active TAM Receptor Kinase

Gajiwala, Ketan S., Grodsky, Neil, Bolaños, Ben, Feng, Junli, Ferre, RoseAnn, Timofeevski, Sergei, Xu, Meirong, Murray, Brion W, Johnson, Ted W., Stewart, Al

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 4.66 MB

english, 2017

35

Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer

Bradshaw-Pierce, Erica Lynn, Pitts, Todd M., Tan, Aik-Choon, McPhillips, Kelly, West, Mark, Gustafson, Daniel L., Halsey, Charles, Nguyen, Leslie, Lee, Nathan V., Kan, Julie L. C., Murray, Brion Willi

Journal:

Frontiers in Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.29 MB

english, 2013

36

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models

Pitts, Todd M., Kulikowski, Gillian N., Tan, Aik-Choon, Murray, Brion W., Arcaroli, John J., Tentler, John J., Spreafico, Anna, Selby, Heather M., Kachaeva, Maria I., McPhillips, Kelly L., Britt, Blai

Journal:

Frontiers in Pharmacology

Year:

2013

Language:

english

File:

PDF, 2.26 MB

english, 2013

37

Countering Breast Cancer's Counterpunch

Murray, Brion W.

Journal:

Molecular Cancer Therapeutics

Year:

2019

File:

PDF, 240 KB

2019